Evaluation of REST expression levels in lung cancer cell lines: potential use as a diagnostic tool
Keywords:
REST, Biomarker, SCLC, Evaluation, Cell linesAbstract
The aggressiveness of small cell lung cancer (SCLC) is associated with the ability of cancer cells to metastasize. Previous studies have demonstrated the role of REST (RE-1 Silencing Transcription factor) in regulating the neuronal phenotype of SCLC, highlighting its importance as a potential diagnostic target. The aim of this study was to determine whether there is differential REST expression among cell lines from different stages of SCLC, using protein analysis via Western blot. The results showed differential expression of canonical REST in the different cell lines, demonstrating decreased levels and the appearance of truncated REST (tREST) in advanced stages of cancer. These studies constitute some of the first evidence of REST as a potential biomarker for SCLC.
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Copyright (c) 2026 Carlos Ortuño , Ricardo Martínez , Adán Arizmendi , Molina Llamas, Adela Sánchez Ocegueda, Yurely Harrinson , Vázquez Berra, Amalia Vences , Jesús Valdés (Autor/a)
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