188 C/A polymorphisms in the LEP gene and K109R in LEPR in a group of mother-neonatal pairs and their association with gestational weight gain and neonatal anthropometry
Keywords:
Polymorphisms, gestational weight, anthropometry, mothers, neonates, anthropologyAbstract
Genes, environmental factors, and lifestyle play an important role in the development of obesity. Leptin, through the action of its receptor, regulates weight gain by decreasing food intake and increasing energy expenditure; it is also an important hormone in embryonic and fetal development. The objective of this study was to determine the genotypic frequency of the -188 C/A polymorphism in the LEP gene and the K109R polymorphism in the LEPR gene in mothers and their newborns and to evaluate their relationship with maternal gestational weight gain and anthropometric parameters in newborns. Ninety-one mother-newborn pairs from the state of Guerrero, Guerrero, and attending the Hospital de la Madre y el Niño Guerrerense were included. All participants underwent body composition analysis, and maternal gestational weight gain was classified according to the criteria of the Institute of Medicine (IOM) of the United States. Quantitative determination of leptin and its soluble receptor (sLEPR) was performed using the ELISA method (Biovendor) on maternal peripheral blood and umbilical cord blood samples. The -188 C/A and K109R polymorphisms were genotyped by PCR-RFLP. Maternal and umbilical cord leptin levels were found to be related to gestational weight gain and neonatal anthropometry. The K109R polymorphism in the leptin receptor was associated with gestational weight gain, placental weight, and neonatal anthropometry.
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Copyright (c) 2026 Guzmán Guzmán, Monzerrath Rodríguez , Beatriz Nava , Sarai Morales , Adiel Molina , José Francisco Muñoz , Isela Parra (Autor/a)
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